When complexity matters: a step-by-step guide to incorporating a complexity perspective in guideline development for public health and health system interventions

Background Guidelines on public health and health system interventions often involve considerations beyond effectiveness and safety to account for the impact that these interventions have on the wider systems in which they are implemented. This paper describes how a complexity perspective may be adopted in guideline development to facilitate a more nuanced consideration of a range of factors pertinent to decisions regarding public health and health system interventions. These factors include acceptability and feasibility, and societal, economic, and equity and equality implications of interventions. Main message A 5-step process describes how to incorporate a complexity perspective in guideline development with examples to illustrate each step. The steps include: (i) guideline scoping, (ii) formulating questions, (iii) retrieving and synthesising evidence, (iv) assessing the evidence, and (v) developing recommendations. Guideline scoping using stakeholder consultations, complexity features, evidence mapping, logic modelling, and explicit decision criteria is emphasised as a key step that informs all subsequent steps. Conclusions Through explicit consideration of a range of factors and enhanced understanding of the specific circumstances in which interventions work, a complexity perspective can yield guidelines with better informed recommendations and facilitate local adaptation and implementation. Further work will need to look into the methods of collecting and assessing different types of evidence beyond effectiveness and develop procedural guidance for prioritising across a range of decision criteria

PROVISIONAL RESTORATIONS IN RESTORATIVE DENTISTRY

Provisional restorations are of a great significance in fixed prosthodontic rehabilitation, particularly in case long-term treatment is needed before final prosthetics. The restorations are also important from the point of view of diagnosis and treatment plan assessment so they should be similar to the final constructions in their shape and function. Provisional restorations quite often need alterations and adjustment to the new requirements, so it’s important to comprehend the compositional properties of the base and repair materials to make a reliable bond between them. Thus, interim treatment should meet a number of requirements such as biocompatibility, marginal adaptation, strength and longevity. The purpose of this review is to discuss fabrication technology of provisional restorations, possible failure and complications, the ways to correct them as well as the aspects of relining provisional restoration.Provisional restorations are of a great significance in fixed prosthodontic rehabilitation, particularly in case long-term treatment is needed before final prosthetics. The restorations are also important from the point of view of diagnosis and treatment plan assessment so they should be similar to the final constructions in their shape and function. Provisional restorations quite often need alterations and adjustment to the new requirements, so it’s important to comprehend the compositional properties of the base and repair materials to make a reliable bond between them. Thus, interim treatment should meet a number of requirements such as biocompatibility, marginal adaptation, strength and longevity. The purpose of this review is to discuss fabrication technology of provisional restorations, possible failure and complications, the ways to correct them as well as the aspects of relining provisional restoration

Optical transition radiation in fused quartz under external acoustic field

In the present paper we have investigated the optical transition radiation in a plate excited by a longitudinal acoustic wave. The spectral-angular density of the radiated energy is calculated. The numerical examples are given for a plate of fused quartz. These results show that the acoustic waves allow to control the parameters of the radiation. In particular, new resonance peaks appear in the spectral distribution of the radiation intensity. The height of the peaks can be tuned by choosing the parameters of the acoustic wave

Восстановление оттока желчи при повреждении гепатикохоледоха и несостоятельности билиобилиарного анастомоза после лапароскопической холецистэктомии

The aspect of injuring bile ducts during laparoscopic cholecystectomy is still of current concern. Causes of this complication include insufficient experience of surgical team, poor knowledge of topographic anatomy of subhepatic space, particularly when perivesical inflammatory infiltrate presents, inadequate approach conversion and so on. Most of patients with bile duct injuries undergo repeated operation in the same surgical unit where cholecystectomy was performed. In many cases, this results in a shortening of the segment of the common hepatic duct, which is favorable for restoration. Subsequent reconstructive surgery is usually performed in the worse conditions with a high risk of complications such as failure of sutures, biliary fistula, anastomotic stricture, etc. Most specialists recommend to abstain from primary reconstruction of the biliary tree in hospitals with no proper experience in hepatobiliary surgery and to perform only the external drainage of subhepatic space with subsequent admission of patient to a specialized clinic. We report a case of a young woman who suffered an excision of hepaticocholedochus fragment during laparoscopic cholecystectomy. A primary reconstructive surgery (hepatico-hepaticoanastomosis) was performed in the same clinic and resulted in external fistula of the common hepatic duct. The subsequent operation (hepaticoejunostomy) was performed in a specialized department of the regional clinical hospital. The woman underwent right-sided hypochondrium laparotomy with debridement of postoperative scar tissues. The stumps of common bile duct were mobilized in compact inflammatory infiltrate. The operation ended with distal stump closure and hepaticoenteroanastomosis formation. The patient was discharged with recovery. Six months later, her condition was satisfactory, and she was engaged in occupational activity.Проблема повреждений желчных протоков во время лапароскопической холецистэктомии не теряет свою актуальность. Причины осложнений: недостаточный опыт хирургической бригады, ограниченные знания топографической анатомии подпеченочного пространства, особенно в условиях перивезикального воспалительного инфильтрата, несвоевременная конверсия доступа и прочее.Большую часть больных с травмой желчных протоков повторно оперируют в хирургических отделениях, где выполняют холецистэктомию. Нередко это заканчивается несостоятельностью билиобилиарного анастомоза и приводит к укорочению перспективного для восстановления сегмента общего печеночного протока.Последующую реконструктивную операцию выполняют в худших условиях с высокой вероят­ностью различного рода осложнений (несостоятельность швов, желчный свищ, стриктура анастомоза и прочее). Большинство авторов рекомендуют воздержаться от первичных реконструкций билиарного дерева в стационарах без должного опыта гепатобилиарной хирургии и ограничиться санацией и наружным дренированием подпеченочного пространства с последующим направлением пациента в специализированные клиники. Представлено клиническое наблюдение лечения молодой женщины, которой во время лапароскопической холецистэктомии иссечен фрагмент гепатикохоледоха.В этой же клинике выполнена первичная реконструктивная операция (гепатикогепатикоанастомоз), после которой сформировался наружный свищ общего печеночного протока. Очередная операция проведена в специализированном отделении областной клинической больницы. Выполнена комбинированная правосторонняя подреберная лапаротомия с иссечением после­операционного рубца. В плотном воспалительном инфильтрате с напластованием фибрина мобилизованы культи общего печеночного протока. Дистальная культя ушита. Сформирован гепатикоэнтероанастомоз. Пациентка выписана с выздоровлением. При осмотре через 6 месяцев состояние удовлетворительное, работает по специальности

Lessons learnt: Undertaking rapid reviews on public health and social measures during a global pandemic

Public health and social measures (PHSM) have been central to the COVID‐19 response. Consequently, there has been much pressure on decision‐makers to make evidence‐informed decisions and on researchers to synthesize the evidence regarding these measures. This article describes our experiences, responses and lessons learnt regarding key challenges when planning and conducting rapid reviews of PHSM during the COVID‐19 pandemic. Stakeholder consultations and scoping reviews to obtain an overview of the evidence inform the scope of reviews that are policy‐relevant and feasible. Multiple complementary reviews serve to examine the benefits and harms of PHSM across different populations and contexts. Conceiving reviews of effectiveness as adaptable living reviews helps to respond to evolving evidence needs and an expanding evidence base. An appropriately skilled review team and good planning, coordination and communication ensures smooth and rigorous processes and efficient use of resources. Scientific rigor, the practical implications of PHSM‐related complexity and likely time savings should be carefully weighed in deciding on methodological shortcuts. Making the best possible use of modeling studies represents a particular challenge, and methods should be carefully chosen, piloted and implemented. Our experience raises questions regarding the nature of rapid reviews and regarding how different types of evidence should be considered in making decisions about PHSM during a global pandemic. We highlight the need for readily available protocols for conducting studies on the effectiveness, unintended consequences and implementation of PHSM in a timely manner, as well as the need for rapid review standards tailored to “rapid” versus “emergency” mode reviewing